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Date 2017/4/17 8:38:19 | Topic: MORTENPARTIET

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"The availability of DAYTRANA, the first and only patch for ADHD, provides physicians and parents with a new, practical way to individualize treatment," said Matthew Emmens, Shire Chief Executive Officer. ADHD is considered the most commonly diagnosed psychiatric disorder in children and adolescents. ADHD is a neurological brain disorder that manifests as a persistent pattern of inattention and/or hyperactivity impulsivity that is more frequent and severe than is typically observed in individuals at a comparable age and maturity.

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Autophagy was shown to be a critical source of nutrients to supply RAS driven human tumours and BrafV600E driven GEMMs of NSCLC (Guo et al, 2011; Strohecker et al, 2013). Using a synthetic lethal RNAi screening approach, White and colleagues identified KRAS and LKB1 co mutant NSCLC tumours to be addicted to coatomer complex I (COPI) dependent lysosome acidification that supplied macromolecules to the TCA cycle. KRAS mutant lung tumours were reliant on lysosomal degradation of macromolecules to fuel catabolic metabolism and showed sensitivity to inhibition of lysosomal maturation (Kim et al, 2013).
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